CORDIS Project
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This project investigates the complex regulatory roles of RNA molecules in bacteria, focusing on cis-antisense RNAs and alternative operon structures. By employing advanced sequencing and computational methods, it aims to uncover how these elements influence bacterial behavior and evolution, particularly in pathogenic…
Pioneering studies from the recent year, including those published by the PI of this proposal, are revolutionizing our perception of prokaryotic transcriptomes, and reveal unexpected regulatory complexity.
Two central concepts are arising: the unanticipated abundance of cis-antisense RNAs overlapping protein coding genes, and alternative transcripts resulting from a dynamic behaviour of operon structures (where genes can be included or excluded from a polycistronic transcript in response to envi…
WEIZMANN INSTITUTE OF SCIENCE
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