CORDIS Project
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This project investigates how the RACK1 protein and the ERK signaling pathway influence the transition between tumor cell proliferation and migration. Understanding this mechanism could provide insights into colorectal cancer progression and potential therapeutic targets.
Recent studies suggest that the microenvironment surrounding primary tumor cells can temporarily change tumor cell gene expression, resulting in suppressed cell proliferation and increased cell motility.
This genetic program allows tumor cells to invade the surrounding tissue, metastasize to distant parts of the body and suppress apoptosis induced by changes in the environment.
Once cells reach a favorable milieu, they suppress migration, reactivate the proliferation program and expand in the ta…
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