CORDIS Project
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DOR-CODE explores how dormant cells maintain their identity and transcriptional memory. By utilizing advanced gene editing techniques, the project aims to uncover the regulatory mechanisms that govern the transition into and out of dormancy, with implications for embryonic development and regenerative medicine.
Decades of work established the importance of dormant cells in reproduction and regeneration, however, a central unsolved question is how the cell propagates transcriptional memory and cellular identity through dormancy.
Current approaches tend to characterize dormancy as a binary on-off switch.
In contrast, a highly coordinated and precisely timed set of events are needed to successfully transition cells into dormancy, to maintain dormancy, and to exit it.
In DOR-CODE, I will leverage the lates…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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