CORDIS Project
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This project investigates the role of prolyl cis-trans isomerization in regulating protein function, particularly focusing on the enzyme Pin1. By exploring this molecular mechanism, the project aims to enhance understanding of protein regulation and its implications for diseases like cancer.
Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function.
Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function.
Proline is the only amino acid in proteins that depending on the value of the ω angle of the peptidic bond can adopt two completely different confor…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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