CORDIS Project
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This project investigates the role of adipose tissue and liver-derived factors in obesity-related liver cancer, specifically hepatocellular carcinoma. By utilizing systems biology and animal models, it aims to identify metabolites that influence tumor growth and immune suppression in the tumor microenvironment.
In obesity, pathological expansion of adipocytes leads to increased adipose tissue macrophage (ATM) amounts and adipocyte death.
Adipocyte death in turn is linked to ectopic lipid spillover and metabolically triggered inflammation which is a risk factor for diseases such as cancer, particularly hepatocellular carcinoma (HCC) that is linked to nonalcoholic steatohepatitis (NASH).
Hepatic fat accumulation leads to chronic hepatocyte metabolic and oxidative stress resulting in cell damage and death…
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