CORDIS Project
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This project aims to understand the dynamic interactions of the 26S proteasome, a molecular machine, using structural biology, biochemistry, and computational methods. It focuses on how the proteasome interacts with proteins and substrates, which is essential for its function and regulation.
To understand how molecular machines execute their function, a multidisciplinary approach combining structural biology with biochemical and computational studies is required.
In this project, I will couple these three methodologies to understand the dynamic interactions and regulatory mechanisms of the 26S proteasome by cryo-EM single particle analysis.Recent work from our lab and others resulted in a pseudo-atomic structure of the 26S proteasome.
At the same time, cryo-EM technology has been re…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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