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The ProTeAN project aims to advance understanding of autism by developing human brain organoids from dental stem cells. This research will explore neurobiological properties and create platforms for drug testing, reducing reliance on animal studies.
Autism and associated neurodevelopmental disorders are chronic conditions that afflict 1 in 68 children and produce great costs to society.
Lack of realistic models has hindered progression in our understanding of these disorders since core pathogenic defects may only arise in the context of complex human neuronal structures.
Two recent breakthroughs have now enabled the development of improved models: the identification of stem cells in adult tissue; and the development of human organoids in vi…
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
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