CORDIS Project
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This project focuses on developing novel probes that target cysteine proteases in tumors for cancer detection and treatment. The probes, known as Photo Dynamic Activity Based Probes, enable real-time imaging and photodynamic therapy, allowing for precise targeting of cancer cells while minimizing damage to surrounding…
Cysteine proteases play pivotal roles in normal and disease processes.
Alteration in cysteine protease expression and activity-pattern are the cause of various human pathologies.
Several different cancers types over express members of the cysteine cathepsin proteases family.
Previously we have designed and developed “smart” quenched Activity Based Probes (qABPs), that enable real time imaging of cathepsin activity in intact cells.
These “smart” probes are fluorescently quenched until binding to…
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