CORDIS Project
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This project investigates the interaction between the alpha-synuclein protein and the human proteasome to understand the mechanisms behind Parkinson's disease. By using advanced experimental techniques, it aims to identify how proteasome activity affects alpha-synuclein aggregation, potentially leading to new therapeut…
Parkinson’s disease (PD) is a severe neurodegenerative disease affecting more than 800000 people in Europe.
Aggregation of the brain protein alpha-synuclein (aS) and its deposition into intracellular inclusions is a crucial event in the pathway leading to the onset of this tremendous disease.
This process is triggered by alterations of the delicate homeostasis between production, aggregation and degradation of aS. aS aggregates are toxic to neurons and have been shown to impair proteasome, the c…
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