CORDIS Project
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This project investigates the role of proteolysis in cancer and neurodegeneration by identifying protease substrates in cellular models. It aims to understand how proteolytic events influence tumor behavior and neuroprotective mechanisms, particularly focusing on the interactions between cancer and stroma cells, as wel…
Proteolysis affects every protein through limited processing or degradation.
Unlike other post−translational modifications, proteolysis is irreversible and occurs intra− and extracellularly.
The large number of genetically encoded proteases in man (> 560) illustrates the importance of proteolysis.
However, the in vivo substrate profiles of most proteases have remained elusive; presenting a major hurdle to understanding protease function in health and disease.System−wide identification of proteas…
UNIVERSITAETSKLINIKUM FREIBURG
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