CORDIS Project
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The ProtecTHY project aims to understand how allogeneic hematopoietic stem cell transplantation affects the thymus, which is crucial for T cell production. By studying the thymus's protective mechanisms, the project seeks to develop strategies to prevent damage and improve patient outcomes after transplantation.
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a common, often last-resort treatment for haematological diseases, but it is plagued by long-term morbidity and high mortality.
Direct alloHSCT-induced damage to the thymus and subsequent loss of thymopoiesis, ie the production of new T cells, is considered one of the main reasons for these complications.
Our limited understanding of how the thymus is damaged during alloHSCT restricts the development of thymus-protecting protocols.…
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