CORDIS Project
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This project focuses on real-time imaging of protein dynamics in liquid environments, utilizing advanced electron microscopy techniques. By observing conformational changes in proteins, it aims to enhance our understanding of their functions, which is crucial for biomedical applications.
The function of many proteins involves large-amplitude domain motions that occur on a timescale of microseconds to millisecond.
In the absence of tools to directly observe these dynamics, our understanding of the function of proteins is necessarily incomplete and must frequently rely on extrapolation from known static structures.
Here, the implementation of real-time imaging of single particle dynamics in liquid phase is proposed with both microsecond time resolution as well as near-atomic spati…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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