CORDIS Project
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This project focuses on engineering a protein capsid for the effective delivery of negatively charged biomolecules into cells. It aims to create a system for encapsulation, transport, and release of molecules like siRNA, potentially advancing gene therapy applications.
The main goal of this project is to develop a system for effective encapsulation and transport of negatively charged guests into living cells using an enginnered protein capsid.
The research in prof.
Hilvert's group demonstrated that it is possible to engineer the inner surface of a capsid formed by lumazine synthase from Aquifex aeolicus (AaLS) to accept positively charged guests while retaining the icosahedral structure.
In my project I will be addressing the following issues: - Engineering th…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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