CORDIS Project
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This research investigates the mechanisms of protein degradation in aging using the model organism Caenorhabditis elegans. It focuses on the interplay between two major protein degradation systems, the ubiquitin/proteasome system and autophagy, to understand their roles in cellular stress responses.
Accumulation of damaged and aggregated proteins is associated with age-related neurodegeneration in Alzheimer’s and Parkinson’s patients.
The ubiquitin/proteasome system (UPS) is a major proteolytic route functioning in a cellular network that maintains the proteome during stress and aging.
Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin (Ub) proteins (ubiquitylation).
Another proteolytic system supporting protein homeostasis (proteostasis) is the a…
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