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The PROTEOFORMER project focuses on developing chemical tools to manipulate specific protein forms, addressing issues related to diseases like Parkinson's. It aims to create targeted reagents that can selectively modify protein functions for therapeutic applications.
The human body can synthesize ~70’000 different proteins.
These proteins diversify into millions of proteoforms, e.g., by associating into complexes or acquiring functionalities called post-translational modifications (PTMs).
Distinct proteoforms are often found in different cell types and have diverse functions.
Dysregulation of specific proteoforms is associated with many diseases, including neurodegeneration or cancers, highlighting the need for their study and modulation.
Despite these needs…
Masarykova univerzita
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