CORDIS Project
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This project investigates how stem cells maintain protein stability to prevent aging. It focuses on the role of proteasome activity in human embryonic stem cells and its implications for understanding aging and related diseases.
While it is has long been noted that genome stability is a central function required for survival of stem cells, the role of protein homeostasis (proteostasis) has not been explored.
With the asymmetric divisions invoked by stem cells, the passage of damaged proteins to daughter cells can destroy the resulting lineage of cells and possibly accelerate the aging process.
Furthermore, the possible retention of damaged proteins by the stem cell can result in diminished stem cell function and possibl…
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