CORDIS Project
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The project aims to develop a novel method for directly measuring proton transfer reactions within proteins, which are essential for biological processes like ATP production. By using light-activated noncanonical amino acids, it seeks to enhance understanding of proton pathways in proteins.
Proton transfer (PT) reactions within proteins are fundamental in biological systems, such as within ATP production.
To date, there are no direct means to measure specific PT pathways within proteins, and most research is based on following the end-product of the PT reaction across a natural proton pathway.
Here, our goal is to develop a novel way to directly measure PT within proteins.
Our new approach is based on placing proton donors and acceptors in specific places within proteins, in which…
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