CORDIS Project
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The PROVASC project aims to uncover protective mechanisms against atherosclerosis, a major cause of cardiovascular disease. By studying the CXCL12/CXCR4 axis, it seeks to enhance understanding of endothelial repair and immune response, potentially leading to new therapies for chronic inflammatory diseases.
Cardiovascular disease including coronary heart disease remains the leading cause of death worldwide.
Atherosclerosis as the underlying pathology is a lipid-driven inflammatory disease of arteries giving rise to vulnerable lesions prone to rupture and thrombotic occlusion.
Lesions develop at predilection sites with disturbed flow, where endothelial damage promotes intimal retention of lipoproteins and inflammatory leukocyte recruitment.
Past research has largely focused on atherogenic factors an…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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