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PROVEC investigates the role of endothelial cells in bone health and regeneration. The project aims to understand how these cells contribute to bone formation and how they can be manipulated to treat conditions like osteoporosis.
The skeletal system and its vasculature form a functional unit with great relevance in health, regeneration, and disease.
Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, its changes during aging, the heterogeneity and functional specialization of bone capillaries and endothelial cells, the regulation of these properties by Notch and hypoxia-inducible factor signaling, and the crosstalk with osteoblast lineage cells.
Most importantly, we f…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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