CORDIS Project
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This project investigates how the location of limb amputation affects regeneration in the axolotl, focusing on cell growth and tissue mechanics. By combining biology with mathematical modeling, it aims to uncover the relationship between cell adhesion and regeneration, which could inform the development of new biomater…
In several regenerating organisms it has been observed that distally amputated structures grow slower than proximally amputated ones, resulting in an overall time of regeneration that is independent of the tissue to be reformed.
This observation suggests that cell proliferation or cell size could be adjusted with the plane of amputation along the proximo-distal (PD) axis, leading to an interesting scaling behaviour.
It has been proposed that positional identity in the limb may be encoded as a pr…
TECHNISCHE UNIVERSITAET DRESDEN
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