CORDIS Project
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This project focuses on developing a new class of biocatalysts that utilize proline-based mechanisms for efficient carbon-carbon bond formation. By engineering enzymes with enhanced properties, the aim is to create environmentally friendly synthetic methodologies.
Proline and related secondary amines were found to be efficient organocatalysts of aldol, alkylation, Michael addition, and other challenging bond-forming reactions.
The design of even more efficient systems that would allow extending this remarkable catalytic strategy to a useful and environmentally benign synthetic methodology would be highly desirable.
This proposal aims to develop a new class of biocatalysts that use the powerful proline-based enamine mechanism of organocatalysts but that ta…
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