CORDIS Project
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This project investigates the role of the splicing factor PRP8 in the regulation of flowering in Arabidopsis by examining its effects on RNA metabolism and chromatin silencing of the FLOWERING LOCUS C gene. The research aims to uncover the molecular mechanisms of RNA-dependent transcription regulation and its implicati…
The project will exploit recent work in Arabidopsis (in the Dean laboratory) linking RNA metabolism and chromatin silencing (Liu et al 2009).
The Dean group is focused on RNA-mediated chromatin regulation of an important repressor of flowering called FLOWERING LOCUS C (FLC).
The concepts that have emerged from this study have wide relevance in many organisms.
Conserved RNA 3’ processing factors function with an RNA-binding protein to target polyadenylation to a specific site in the FLC antisense…
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