CORDIS Project
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This project investigates the radial arrangement of nuclear proteins in mammalian cells, particularly during differentiation of induced pluripotent stem cells. It aims to develop a tool for mapping these proteins and exploring their functional relevance in gene expression and cell identity.
Recent evidence gathered in the Bienko Lab indicates that, in addition to DNA, many nuclear proteins including several transcription factors implicated in cell fate determination are non-randomly radially distributed in the nucleus of mammalian cells.
This fascinating observation led me to hypothesize that there exist a broad set of nuclear proteins that are arranged along radial gradients in the nucleus, acting as readers of the radial genome architecture.
Within this MSCA Postdoctoral Fellowsh…
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