CORDIS Project
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The PSDisrupt project aims to develop antiviral drugs targeting viral replication mechanisms in emerging DNA viruses like monkeypox and African swine fever. By utilizing artificial intelligence to design inhibitors, the project seeks to create effective treatments and explore broader applications in various diseases.
The phylum Nucleocytoviricota includes (re-)emerging dsDNA viruses of major concern, such as monkeypox virus (mpox) and African swine fever virus (ASFV).
Despite their economic and public health impact, no formally approved antivirals exist for these pathogens.
Viral factories (membrane-less organelles essential for replication) are highly conserved across Nucleocytoviricota, presenting an attractive and untapped target for antiviral intervention.PSDisrupt builds on findings from the ERC-funded…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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