CORDIS Project
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The project investigates the use of autotaxin inhibitors to treat psychiatric disorders by reducing cortical hyperexcitability. This approach has shown promise in animal models for schizophrenia, aiming to advance these treatments towards clinical application.
Within the frame of the ERC LiPsyD we have shown that recently discovered that the phospholipid LPA acts as a synaptic modulator playing a major role in regulating cortical excitability and being involved in psychiatric disorders (Trimbuch et al., 2009;
Unichenko et al., 2016;
Vogt et al., 2016;
Vogt et al., 2017).
Using specific small molecule inhibitors like PF8380, which target the LPA-synthesizing molecule autotaxin (ATX), we were able to decrease cortical hyperexcitability and to rescue dis…
UNIVERSITAET MUENSTER
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