CORDIS Project
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This project investigates the role of energy sensing pathways in prostate cancer progression, focusing on the interaction between the LKB1 kinase and the PTEN tumor suppressor. Using genetically modified models, it aims to understand how these pathways influence cancer development and identify potential therapeutic str…
Prostate cancer is among the most prevalent forms of cancer in men and the fifth cause of dead from cancer in men worldwide.
Therefore, the understanding of prostate cancer biology is a key step in the development of new effective therapeutic approaches.
In this line, the use of genetically engineered mouse models has been critical in the understanding of the genetic cues that regulate the process of prostate epithelial cell transformation.
We have previously characterized the tumor suppressive…
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