CORDIS Project
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This project explores the engineering of genetically encoded peptides to develop novel antibiotics. It focuses on understanding posttranslational modifications to enhance peptide stability and bioactivity, aiming to create a flexible system for discovering new antibiotic compounds.
The rise of pathogenic bacteria that are resistant against a variety of antibiotic treatment emphasizes the need for novel active molecules.
One promising novel class of active molecules is genetically encoded and ribosomally synthesized peptides, as they offer the potential to employ directed evolution approaches across a huge sequence space directly on an active substance in order to engineer novel activities and thus introduce a novel engineering principle into antibiotic development.
However…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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