CORDIS Project
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This project investigates the regulation of Epidermal Growth Factor signaling by Protein Tyrosine Phosphatases in living cells. Using advanced imaging techniques, it aims to understand how these enzymes influence cell signaling dynamics and specificity, which is crucial for addressing diseases like cancer and diabetes.
Receptor tyrosine kinases (RTK) are involved in the regulation of cell proliferation, survival, differentiation and motility upon binding of growth factors.
Disturbance of the normal balance between tyrosine kinase and Protein Tyrosine Phosphatase (PTP) activity results in aberrant tyrosine phosphorylation and has been implicated in the etiology of several human diseases, including cancer, diabetes and inflammation.
Thus, it is important to understand how phosphorylation is regulated by members…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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