CORDIS Project
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This project investigates how signaling pathways influence the behavior of epidermal stem cells, focusing on the ERK pathway. By analyzing the dynamics of ERK signaling, it aims to control stem cell states and understand their implications for regenerative medicine.
Understanding how stem cells maintain homeostasis in the epidermis is of great interest to regenerative medicine.
Previous studies have identified the crucial role ERK signalling plays in coordinating homeostasis.
Intriguingly, and somewhat paradoxically, ERK signalling has been shown to regulate divergent epidermal stem cell outputs; from maintenance, to commitment, and terminal differentiation.
Uncovering how the activity of a single signalling pathway can regulate such divergent responses can…
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