CORDIS Project
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This project investigates the self-assembly of phenol soluble modulins from Staphylococcus aureus and their role in pathogenicity. It aims to uncover the mechanisms behind their multifunctionality and how they interact with biological membranes, potentially leading to new therapeutic strategies.
An important challenge in biophysics is to understand the complex biological functions emerging from the physico-chemical properties of simple building blocks.
Showcasing this challenging question is the multiple functions achieved by the phenol soluble modulins (PSMs) peptides from Staphylococcus aureus, able to self-assemble into amyloid structures, and underlying S. aureus pathogenicity.
Over the past decade, the intrinsic capacity to form fibrils in vitro has been directly correlated with th…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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