CORDIS Project
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This project explores how to manipulate protein-protein interactions using small molecules, focusing on a specific protein complex involved in cellular oxygen sensing. By understanding these interactions, the project aims to contribute to drug discovery and the development of new therapeutics for cancer and related dis…
Most proteins exert their biological function by interacting with other proteins in complex macromolecular assemblies.
Modulating protein:protein interactions (PPIs) using small drug-like molecules has the potential to unlock new horizons for chemical biology and developing novel therapeutics.
However, this task has proven difficult because of the diverse, complex and dynamic nature of PPI interfaces.
This project aims at investigating the plasticity and druggability of PPI interfaces within mul…
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