CORDIS Project
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This research investigates the development and migration of pyramidal neurons in the brain during embryonic stages. It aims to understand how these neurons manage polarity and axon growth, which are crucial for proper brain circuitry and can impact various neurological disorders.
During embryonic brain development, pyramidal projection neurons are born in the ventricular zone and migrate radially towards the upper part of the cortex to form the cortical plate.
These neurons also have to develop dendrites and axons in order to make connections.
Several brain diseases and mental illness derive from defects in neuronal migration and positioning or in axon-target interactions for the establishment of synaptic circuitry.
Studies with cultured pyramidal neurons have shown tha…
UNIVERSITE CATHOLIQUE DE LOUVAIN
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