CORDIS Project
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This project focuses on developing selective inhibitors for the enzyme Dipeptidyl Peptidase 9, which induces a specific form of cell death in Acute Myeloid Leukemia cells. By utilizing targeted delivery methods, the project aims to enhance the therapeutic potential of these inhibitors while ensuring safety and selectiv…
DPP9 (dipeptidyl peptidase 9) is a cytosolic serine protease.
It recognizes and cleaves N-terminal dipeptides containing proline at the penultimate position.
The enzyme is currently receiving strong international attention after it was reported that DPP9 inhibition induces inflammatory cell death (pyroptosis) in Acute Myeloid Leukemia (AML) cells.
Pyroptosis is a lytic form of cell death that also causes a pronounced, local upregulation of the innate immune system.
This is of particular interest…
UNIVERSITEIT ANTWERPEN
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