CORDIS Project
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This project investigates the formation and characteristics of G-quadruplex structures in cellular environments, aiming to develop targeted drugs for these structures. It employs advanced spectroscopic techniques and mass spectrometry to explore ligand interactions and nucleic acid folding within cells.
Nucleic acids are intrinsically polymorphic.
Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands.
It is now proven that G-quadruplexes can form in cells.
Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents.
Still, recent works suggest that the folding of G4s may differ in the c…
Masarykova univerzita
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Germany, Frankfurt Am Main
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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