CORDIS Project
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This project aims to explore the structural biology of G-quadruplexes in living cells and develop specific drugs targeting these structures. It focuses on understanding nucleic acid folding and enhancing drug design through innovative biophysical techniques.
Nucleic acids are intrinsically polymorphic.
Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands.
It is now proven that G-quadruplexes can form in cells.
Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents.
Still, recent works suggest that the folding of G4s may differ in the c…
Masarykova univerzita
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