CORDIS Project
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The QS21-Mech project aims to investigate the molecular mechanisms of saponin adjuvants, particularly QS-21, to enhance vaccine efficacy. By developing synthetic probes and utilizing chemical proteomics, the project seeks to identify the molecular targets of these adjuvants, ultimately improving vaccine design and effe…
Adjuvants are vital components of modern molecular vaccines that increase the low immunogenicity of subunit peptide and/ or polysaccharide antigens and potentiate the immune response.
Despite their key role, the mechanisms of action of many adjuvants, including the clinically-relevant saponin QS-21, are poorly understood, which hampers the rational design of new, improved vaccine adjuvants.To address this gap and shed light into this fundamental biological mystery, the main goal of this proposal…
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