CORDIS Project
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This project investigates Quiescin sulfhydryl oxidase (QSOX), an enzyme involved in protein cross-linking and extracellular matrix formation, particularly in relation to cancer. It aims to understand QSOX's role in tumor microenvironments and explore its potential as a target for anti-metastatic therapies.
Quiescin sulfhydryl oxidase (QSOX), which catalyzes disulfide cross-linking in proteins, is up-regulated in many tumor types. QSOX is the only disulfide catalyst to undergo regulated secretion from cells, but the biological role of the enzyme, its substrates, and its mechanistic link to cancer are obscure.
In addition to determining the first X-ray crystal structures of QSOXs, we recently discovered that QSOX is required for incorporation of laminins into basement membrane extracellular matrix (…
WEIZMANN INSTITUTE OF SCIENCE
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