CORDIS Project
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This project investigates the role of primary cilia in sensing nutrient availability and their communication with mitochondria. It aims to understand the mechanisms behind this interaction and its implications for diseases related to cilia dysfunction.
Primary cilia are single, microtubule-based, organelles protruding as antennae at the surface of most cells.
Their dysfunction is associated with several genetic disorders, called the ciliopathies.
We recently identified a new, previously undescribed, role for primary cilia as sensors of cellular nutrient availability.
In this novel mTORC1-independent pathway, cilia directly communicate with mitochondria to drive metabolic reprogramming under nutrient stress, when glutamine (Q) becomes an obliga…
OSPEDALE SAN RAFFAELE SRL
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