CORDIS Project
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This project explores the mechanisms of protein quality control in yeast, focusing on how damaged proteins are segregated and detoxified. It aims to uncover genetic interactions that could lead to new therapeutic targets for age-related diseases.
Propagation of a species requires periodic cell renewal to avoid clonal senescence.
Mylaboratory has described a new mechanism for such cell renewal in yeast, in which damagedprotein aggregates are transported out of the daughter buds along actin cables to preserveyouthfulness.
Such spatial protein quality control (SQC) is a Sir2p-dependent process and by establishing the global genetic interaction network of SIR2, we identified thepolarisome as the machinery required for mitotic segregation and…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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