CORDIS Project
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This project focuses on understanding the lifecycle of transfer RNA (tRNA) in human cells, particularly how chemical modifications affect their function and stability. It aims to uncover mechanisms behind tRNA-related neurodevelopmental disorders using advanced cellular models.
By delivering amino acids to translating ribosomes, transfer RNAs (tRNAs) are central to protein synthesis.
These small (~76 nucleotide-long) molecules have very similar three-dimensional structures, which must withstand substantial conformational changes throughout the tRNA lifecycle.
To meet these demands, tRNAs are decorated by diverse chemical modifications at multiple nucleotides by highly conserved enzymes.
Defects in the genes encoding these enzymes are linked to neurodevelopmental disord…
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