CORDIS Project
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This research focuses on understanding the quality control mechanism in cells that degrades faulty messenger RNA, specifically those with premature termination codons. It aims to explore how this process affects genetic diseases and gene expression.
Analogous to quality control checks along the assembly line in industrial manufacturing processes, cells possess multiple quality control systems that ensure accurate expression of the genetic information throughout the intricate chain of biochemical reactions. “Nonsense-mediated mRNA decay” (NMD) represents a quality control mechanism that recognizes and degrades mRNAs of which the protein coding sequence is truncated by the presence of a premature termination codon (PTC).
By eliminating these…
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