CORDIS Project
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This project investigates chloride transport in human pancreatic duct cells to understand its role in organ function. It combines various techniques to explore the mechanisms of transport and the cellular response to perturbations.
Solute transport across epithelial cells is of vital importance for the function and development of many organs, for instance, the pancreas, liver, and intestine.
Within the pancreas, bicarbonate is secreted from the ducts in order to neutralize stomach acid in the duodenum.
The secretion of bicarbonate over the epithelial membrane is coupled to chloride transport in the opposite direction.
The mechanism of this transport is complex due to the redundancy of transporters, protein-protein interact…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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