CORDIS Project
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This project investigates the mechanisms behind chromosome segregation during the first meiotic division in mouse oocytes. It aims to understand how spindle positioning and chromosome dynamics are coordinated to ensure accurate cell division.
Cell division is a fundamental biological process: faithful chromosome segregation is important to maintain genome stability.
The first meiotic division is a unique type of chromosome segregation for two main reasons.
First, it segregates homologous chromosome pairs rather than sister chromatids, as it occurs in mitosis.
Second, the chromosomes are segregated only when the meiotic spindle has been positioned at the cortex of the oocyte.
This division is extremely asymmetric to preserve the store…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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