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This research focuses on the role of protein fatty-acylation in immune response, particularly how S-palmitoylation affects the function of proteins involved in pathogen clearance. It aims to develop methods to quantify these modifications in immune cells.
Protein fatty-acylations (N-myristoylation, S-palmitoylation and Lys-fatty acylation) are important lipid-modifications that regulate the trafficking and function of membrane-associated proteins in eukaryotes.
With the development of new chemical proteomic methods by the Hang laboratory and others, many additional protein candidates of fatty-acylation have been reported.
Notably, the Hang group has recently discovered several fatty-acylated proteins which are directly involved in host resistance…
THE FRANCIS CRICK INSTITUTE LIMITED
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THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION
United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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