CORDIS Project
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This project aims to develop a biocatalytic method for producing enantiopure atropisomeric drugs, addressing inefficiencies in current production methods. By utilizing enzymatic deracemisation, the approach targets polar, water-soluble drug candidates, potentially transforming the production processes in medicinal chem…
Drugs that are chiral due to slow bond rotation (atropisomeric) are becoming more prevalent, and atropisomerism is increasingly recognised as an asset rather than a hindrance in medicinal chemistry programmes.
However, although some asymmetric routes to atropisomers are established, very few methods are applicable to ‘drug-like’ atropisomers – namely those that are heavily functionalised, hydrophilic and often heterocyclic target molecules, meaning that enantiomerically pure atropisomeric drug c…
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