CORDIS Project
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This project investigates autosomal monoallelic expression, an epigenetic mechanism regulating gene expression from maternal and paternal alleles. By analyzing genome-wide patterns and identifying regulatory elements in mice and humans, the research aims to clarify the genetic control of this phenomenon and enhance und…
Autosomal monoallelic expression (MAE) is an epigenetic phenomenon that controls the relative expression of maternal and paternal alleles in thousands of mammalian genes.
Despite MAE’s widespread character the molecular mechanisms involved in its establishment and maintenance are yet to be clarified.
Recent work shows that the sets of genes subject to MAE are highly consistent across individuals and conserved between human and mouse species. I propose to test that such conservation is due to spe…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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