CORDIS Project
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This project develops a new method for studying chromatin dynamics in cells, focusing on how gene expression is regulated during the cell cycle. It aims to uncover the stability of chromatin states and their inheritance across generations.
Histone proteins provide a dynamic packaging system for the eukaryotic genome.
Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division.
For our understanding of cellular memory and epigenetic inheritance we need to know what features characterize a stable, heritable chromatin state throughout the cell cycle.
State-of-the-art methods such as ChIP-Seq provide population-based snapshots of…
KAROLINSKA INSTITUTET
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