CORDIS Project
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This project focuses on the role of Ras genes in health and disease, particularly in cancer and developmental disorders. By using mouse models, it aims to elucidate the functions of Ras proteins in normal physiology and their implications in tumorigenesis.
Ras genes are some of the best-studied genes in biomedical research due to their central role in mitogenic signaling and their oncogenic activation in one third of all human tumors.
More recently, Ras genes have also been implicated in developmental disorders including Costello and Noonan syndromes.
In spite of this wealth of information, we still do not know the role of Ras proteins in adult homeostasis and, more importantly, how their misregulation affects human health.
The latter is of paramo…
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