CORDIS Project
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This project investigates the molecular mechanisms of Ras proteins, which are critical in cancer signaling pathways. By employing bioinformatics and computational methods, it aims to understand how Ras interacts with its effectors, focusing on their flexibility and binding dynamics to enhance knowledge of cancer biolog…
Ras genes code for small GTPases that act as GDP/GTP-regulated molecular switches.
This exchange induces a conformational change that allows them to interact with their downstream effectors, and thus participate as central control elements in signal transduction.
Mutated forms of the Ras oncoprotein are found in more than 30% of all human cancers, justifying the extensive research on them.
Ras effectors have convergently developed a common subdomain in their unrelated overall structure for…
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