CORDIS Project
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This project focuses on identifying kinase mutations in specific subtypes of breast cancer that currently lack targeted therapies. By exploring the kinome of these tumors, the aim is to discover novel therapeutic targets and validate them through preclinical and clinical trials.
Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components.
While there are several ongoing large-scale genome re-sequencing studies for the major cancer types, there is no systematic effort to investigate kinase mutations in distinct biological subtypes of these cancers.
Here, we will explore the rate of activation of all kinases (the “kinom…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
Sweden, Lund
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
FUNDACION PRIVADA INSTITUTO DEINVESTIGACION ONCOLOGICA DE VALL-HE
Spain, Barcelona
Type: Research institute
Activity type: Research Organisations
SME: No
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